02 Purine
- direct synthesis from building blocks
- salvage: breaks down DNA, salvage bases
- amino: amine group
Purine Synthesis
- A and G: nitrogen group
- adding phosphate groups to 1 C
- THF from vitamin folate, important for thymidine and purine
- folate: single carbon donor
Salvage
- salvaging pathway inhibited
Excretion
- under excretion: furosemide
- overproduction
