03 Renal Physiology 1

  • only in extracellular space, injected
  • albumin: only in plasma, not interstitial

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  • only portion of fluid perfusing tissues
  • theoretical volume

  • TBW: total body water

Kidney Function

  • sufficient urine = kidney working, but very crude measurement

  • filtration fraction: percentage of all blood in kidney filtered
  • FF: RPF not RBF

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  • yellow: bowman space

  • left: high osmotic pressure
  • right: low osmotic pressure
  • high pressure draw water away from low pressure side

  • high oncotic pressure in glomerulus, but even higher hydrostatic pressure that drive water out into bowman's space

  • FF same

  • decreased renal plasma flow overall, less blood perfusion kidney
  • increase FF

  • multiple myeloma
  • same amount of blood in and out of kidney (afferent = efferent)