04 Virus Structure

  • glycoproteins for attachments

Capsid

  • both made by multiple identical copies of proteins

Envelopes

  • icosahedral shape very stable. If not envelope = icosahedral shape

  • envelope virus can't survive in environment, not transmitted fecal oral or contaminated water
  • Hep B/Herpes/HIV all transmitted directly

RNA

  • host cell synthesize proteins using +RNA

  • top: + RNA, synthesize directly to proteins
  • middle: -RNA, nucleic acid not make sense, can't be translated
  • RNA polymerase flip 3' and 5' end and also flip the bases

  • no human enzyme available to make RNA from RNA

+RNA

  • RNA in cell, immediately translated
  • one of translated is RNA polymerase that makes - RNA and also translate - RNA to + RNA genome

-RNA

  • positive intermediate RNA translated and made into -RNA genome

Retro

DNA

Infectivity

  • whether or not nuclear material can cause infection by themselves

Segmented

  • reassorments: pandemics

  • papilloma, polyoma, hepadna all have circular DNA