05 Pedigree

  • affecting both male/female
  • most people don't have disease
  • middle: both people don't have disease but are carriers

AD

  • males/females affected
  • 50% offspring have disease
  • male to male transmission occurs (pass Y), not X linked

X linked

  • one of X becomes inactive

  • different cells in females will have different lyonization
  • skewed lyonization: more healthy X become lyonized

X Dominant

Mitochondrial

  • confusion from CNS effects
  • lactic acidosis from no aerobic metabolism

Polygenetic