05 Pharmacokinetics

  • method apply drug affect how much bioavailable
  • percent to blood stream

  • compare area under curve for oral with area under curve for IV

  • 1st steep decline: reaching steady state in body
  • C0: concentration if drug immediately distribute equally in body

  • large/charged: can't leave vascular compartment
  • chloroquine: large amount in tissue, little in blood stream. Back calculation = large number

  • greater effects/SE when more unbound drug move to tissues
  • metabolized/excreted faster

  • elimination constant: how quickly kidney clears a volume of plasma
  • greater the volume of distribution, greater the clearance (remove same number of molecules but in more plasma)
  • clearance not amount of drug held by kidney but amount of volume cleared of drug

  • higher the clearance, higher elimination constant

  • 4 half lives to get drug out of body

  • immediately to 20