08 Bile
Synthesis
- bile salts made from bile acids (cholic acid, cheno)
- bile acids conjugated to another hydrophilic structure
Function
Cholesterol
Antimicrobial
Lipid Absorption
- bile main way bilirubin eliminated
- increase SA for pancreatic lipase to work
- emulsify lipids
- bile salt surround lipids with hydrophobic and hydrophilic sides
- enterohepatic circulation: some reabsorbed
- 5%: cholesterol elimination
Cholestasis
- caused by stones, mass, strictures
- alk phosphatase: synthesized by bile duct epithelium
- dilated bile duct from obstruction
- epithelium creates alk phos
- some liver damage due to back flow
- intrahepatic: nl bile duct
- extrahepatic: dilated bile duct
- estrogen can lead to bile flow obstruction
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