08 Bone Biology

  • trabeculated: honey combed

  • center: medullary cavity
  • top: porous, trabeculated, end of long bone

  • osteoclast slave to osteoblast

Formation

  • 2 ossifications grow towards each other and trap epiphyseal plate

  • layer of cartilage trapped = growth plate

  • chondrocytes grow toward epiphysis
  • osteoblast grow towards diaphysis

  • woven bone remodeled by osteoblast

  • Hunter's and Hurler's cannot metabolize mucopolyssachrides

  • all these go up in increased activity

  • acidosis bad for bone formation
  • chronic acidosis: bone break down