13 Insulin

Rapid acting insulin

  • Glulisine, aspart, lispro.
  • Girls and lads

.

Regular Insulin

.

  • made with bacteria

.

  • same onset as rapid acting when given IV

NPH Insulin

.

  • replaced often by Glargine and Detemir

Glargine

.

  • often given as basal insulin once a day plus bolus rapid action
  • form crystals that dissolve slowly once in body

Detemir

.

  • absorb slowly once in SQ tissue
  • less weight gain than Glargine

Insulin Analogs vs insulin molecules

SE

  • hypoglycemia: tremor, palpitation, anxiety, seizure, coma
  • weight gain: from insulin promotin FA/protein synthesis