14 Liver Disease


Tests

  • enzyme in liver that transfer nitrogen groups between amino acids

  • can use to see if pts drinking
  • 5'-nucleotidase similar enzyme

  • low

Alcoholic

  • chronic leads to cirrhosis

Fatty Liver Disease

  • liver enlarged in heavy drinker = fat deposition

NAFLD

Acute Hepatitis

Budd Chiari

  • ascites: blood can't drain, push into portal system, out into abdomen
  • hepatocellular carcinoma: liver tumor compresses cells into hepatic vein

RHF

Reye

a1 antitrypsin

  • purple deposits
  • glycogen also stain purple

Abscess

Hepatitis

Autoimmune

Tylenol

  • right after ingestion: activated charcoal

Shock

Things cause >1000 ALT/AST:

  • hepatitis
  • tylenol
  • shock