24 Diuretics

  • body maintain 140 meq concentration via water retention/excretion

CA Inhibitors

  • almost never used as diuretics because effect so weak

  • paresthesia common in a number of acid-base disorders (acid-base disruption on nerves)

  • calcium stones from acidemia that prevents citrate excretion

Osmotic Diuretics

  • can't excrete mannnitol, circulate in plasma for long time
  • also cause anuric renal failure (no urine)

Loop

  • really strong, use in edematous state to remove volume
  • decrease gradient of interstitium in inner medulla

Thiazide

  • inhibit NaCl pump, Na/K pump still active, low intracellular Na
  • NaCa exchanger active, lower intracellular Ca
  • Ca pulled from lumen

  • hyperGLUC mnemonic

  • don't produce vigorous output, not good for edematous state

K sparing