25 IBD

Ulcerative Colitis

  • ulcers in colons
  • not full thickness

  • always rectal: LUQ pain

  • an ulcer healing, scar tissue raised up and looks like polyps

  • neutrophils everywhere

Extra-intestinal

  • ulcers in skin
  • number of autoimmune diseases cause uveitis (RA e.g.)
  • lower back pain and joint stiffness, at night

  • colon stops contraction

  • toxic: fever and shock

Crohn's

  • terminal ileum
  • B12, bile salts absorbed in ileum
  • increased risk of gallstones, also secretory diarrhea (draw fluid), and steatorea from fat
  • terminal ileum: RLQ pain

  • stones: normal mucosa
  • fissures: transmural inflammation

  • transmural inflammation spread outside the wall and to other places (bladder, skin)

  • fat wrapped around bowel

ExtraIntestinal

  • lower back pain and joint stiffness at night

Immunology

Smoking

Treatment