40 Demyelinating Diseases

MS

  • weakness of arm, tingling of face, then go away; then second symptoms
  • very very tired after hot shower: less nerve transmission

  • Myelin basic protein one of the antigens
  • type 4 but has antibodies

Symptoms

  • pain/loss of vision in one eye
  • Internuclear ophthalmoplegia: double vision/diplopia
  • bladder: spasm or fail to sense

  • oligoclonal bands: protein of certain size

  • newer agents: don't know how they work

Guillain Barre

  • acute
  • no reflex

  • endoneurium classically affected

  • SCD: sudden cardiac death

  • nonspecific

  • weak respiratory muscles: support breathing

PML

  • poor prognosis

Posteinfectious encephalomyelitis

  • hypodense on imaging

Charcot - Marie - Tooth

  • weakness and severe deformities in lower extremities and feet

Metachromatic Leukodystrophy

Krabbe