Ammonia

  • excess are broken down
  • generic way aa metabolized

  • toxic to brain

  • amino group passed to a keto to become glutamate

Glutamine

Alanine

  • amino group passed to pyruvate to create alanine

  • alanine taken to liver but can’t be metabolized

Urea

  • only in liver

  • high levels of glutamate and acetyl coa in fed state
  • activate urea cycle

  • all area amino acids

  • urea cycle happen in liver

  • if no aa ingested, little aa breakdown

  • only used in children
  • arginine becomes essential

OTC Deficiency

Citrullinemia