Angiotensin II for the Treatment of Vasodilatory Shock by ATHOS-3 trial

• related: ICU intensive care unit
• tags: #literature

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Methods

AII was started at 20 ng/kg/min and adjusted to 1.25-40 ng/kg. Study infusion was discontinued at 48 hour mark.

Results

• Mean reduction of 0.03 ug/kg/h of background vasopressors and increase in MAP within 3 hours.
• Mean improvement in CV SOFA score at 48 hours without improvement in total SOFA score.
• No mortality difference. ¹

Follow up

• Numerous counterpoint. ²
• Follow up study found improvement in 28 day survival, MAP, and rate of RRT liberation.³

Links to this note

• ICU intensive care unit
  • Angiotensin II for the Treatment of Vasodilatory Shock by ATHOS-3 trial

Footnotes

1. https://www.nejm.org/doi/10.1056/NEJMoa1704154 ↩

2. https://emcrit.org/pulmcrit/angiotensin-ii/ ↩

3. https://journals.lww.com/ccmjournal/Fulltext/2018/06000/Outcomes_in_Patients_with_Vasodilatory_Shock_and.15.aspx ↩