Angiotensin II for the Treatment of Vasodilatory Shock by ATHOS-3 trial
- related: ICU intensive care unit
- tags: #literature
- does 2 pressors (levo + ang) increase MAP compared to levo + placebo.
- No survival benefit
- very expensive1
Methods
AII was started at 20 ng/kg/min and adjusted to 1.25-40 ng/kg. Study infusion was discontinued at 48 hour mark.
Results
- Mean reduction of 0.03 ug/kg/h of background vasopressors and increase in MAP within 3 hours.
- Mean improvement in CV SOFA score at 48 hours without improvement in total SOFA score.
- No mortality difference. 2
Follow up
- Numerous counterpoint. 3
- Follow up study found improvement in 28 day survival, MAP, and rate of RRT liberation.4