avoid pulmozyme or dornase alfa in non-cystic fibrosis CF bronchiectasis


  • pulmozyme not useful in non-CF bronchiectasis patients and can actually lead to increased exacerbation and decreased FEV1 1, 2

Footnotes

  1. Bronchiectasis Lecture by Jennifer Krall?

  2. O'Donnell A.E., Barker A.F., Ilowite J.S., et. al.: Treatment of idiopathic bronchiectasis with aerosolized recombinant human DNase I. rhDNase Study Group. Chest 1998; 113: pp. 1329-1334.