common variable immunodeficiency disorder CVID
- related: Pulmonology
- tags: #literature
Pathogenesis
- impaired B cell differentation
Patient population
- often has pneumonia covered by childhood vaccines. Look for encapsulated organisms (H flu, Strep pneumo)
- rare ones include NTM, Cryptococcus
- complement deficiency will also have encapsulated organisms but without bronchiectasis or lung diseases
- hepatosplenomegaly
- bilateral small lung nodules
- bronchiectasis
- mixed obstructive/restrictive PFT
Management
- Check IgM, IgG, IgA 1