DOSE trial showed lasix infusion has no mortality benefit

• related: Cardiology
• tags: #permanent

• low dose bolus or infusion: home diuretic converted to IV equivalent
• high dose bolus or infusion: 2.5x home diuretic converted to IV
• comparing bolus vs infusion, there's no mortality differences, no difference in symptoms, change in Cr
• infusion at higher dose has trend towards faster improvement in symptoms, greater diuresis, but worse renal function.¹

Links to this note

• Cardiology
  • DOSE trial showed lasix infusion has no mortality benefit