Glucocorticoids


Eicosanoids

  • eicosanoids include leukotrienes, PGs, TXs

  • block PGE2: improvement in first 4 conditions with price of renal vasoconstriction

COX

Drugs

NSAIDS

  • effects similar to steroids but not steroids
  • ketorolac: often IM in ER for pain

  • traditional NSAIDS

COX2

Steroids

  • TNF alpha works by activating NF-KB

  • feared complication