Glucocorticoids

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Eicosanoids

• eicosanoids include leukotrienes, PGs, TXs

• block PGE2: improvement in first 4 conditions with price of renal vasoconstriction

COX

Drugs

NSAIDS

• effects similar to steroids but not steroids
• ketorolac: often IM in ER for pain

• traditional NSAIDS

COX2

Steroids

• TNF alpha works by activating NF-KB

• feared complication

Links to this note

• step 1 Immunology
  • Glucocorticoids