Hypersensitivity

Type 1

  • allergies
  • non receptor tyrosine kinase

  • epinephrine: vasoconstrict, increase CO, dilate bronchioles

  • genetic. Multiple sensitivities

  • leukotrienes can be produced quickly as early phase or later as late phase

  • chymase, tryptase specific for anaphylaxis, not serotonin

  • wheal: raised red skin

Type 2

Type 3

  • deposit of complex

  • complex deposits in lots of places, causing systemic diseases

Arthus

  • don't circulate
  • form in tissue locally and cause disease

  • inject first time, no reaction. Third or fourth time, arthus
  • first 3 times, antibody formation. 4th time: reaction

  • booster vaccine: antigen into someone previously exposed to vaccine
  • diabetes repeatedly inject insulin

Type 4