Interstitial pneumonia with autoimmune features challenges and controversies

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Persistent Notes

Highlights

  • interstitial pneumonia with autoimmune features p.1
  • Connective tissue diseases p.1
  • ILD in the presence of features suggestive of, but not confirmatory for, p.1
  • a define p.1
  • CTD. p.1
  • idiopathic interstitial pneumonia p.2
  • n overlap between IIPs and CTD-ILD p.2
  • overlap CTD p.2
  • h features of separate CTD p.2
  • are present in the same patient p.2
  • exposed to inhaled antigens p.2
  • with some IPAF series being “close t p.3
  • IPF cases” and others “closer to CTD-ILD cases”. p.3
  • h abnormal nailfold capillaroscopy p.4
  • salivary gland biopsy, p.4
  • inclusion of selected additional items p.4
  • sicca symptoms p.4
  • Myositis-specific antibodies p.4
  • anti-synthetase antibodies p.4
  • IPAF patients with MSA p.7
  • were more frequently characterised by a computed tomography p.7
  • non-specific interstitial pneumonia p.7
  • ) Interstitial pneumonia with autoimmune features p.8
  • Positive serology for anti-OJ p.8
  • (ANA) p.8
  • rheumatoid factor p.8
  • a UIP pattern. p.8
  • non-UIP histological pattern p.9
  • “multi-compartment involvement”, p.9
  • treatment of gastro-oesophageal reflux i p.13
  • glucocorticoids p.14
  • immunosuppressive therapy p.14
  • cyclophosphamide, followed by maintenance mycophenolate and prednisolone p.14
  • mycophenolate p.14
  • Nintedanib p.15
  • (the INBUILD study) p.15
  • SENSCIS p.15
  • e observation without dru p.15
  • therapy, immunomodulation with glucocorticoids and/or immunosuppressants, antifibrotic drugs, a p.15

Reference

Mackintosh JA, Wells AU, Cottin V, Nicholson AG, Renzoni EA. Interstitial pneumonia with autoimmune features: challenges and controversies. Eur Respir Rev. 2021;30(162):210177. doi:10.1183/16000617.0177-2021