Sweet syndrome

  • aka acute febrile neutrophilic dermatosis
  • pathophysiology: after URI or GI infection, in setting of heme problems such as MDS or myelodysplastic syndrome evolving to AML
  • association with medications that stimulates neutrophils: all-trans retinoic acid, GCS-F
  • sx:
    • high fever
    • neutrophilia
    • leukocytosis with left shift
    • elevated inflammatory markers
    • muscle/joint pain
    • dense dermal infiltrate on histology
    • "juicy" skin lesions: painful, edematous, red to violet
    • no infection, responsive to steroids

mimics cellulitis