timing and frequency of tpa

  • Mist2:
    • tpa followed by 1 hour clamping, followed by DNase, followed by 1 hour clamping
    • BID for 3 days
  • Once daily use of tpa/dornase
    • tpa followed by 1 hour clamp, followed by suction, followed by DNase
    • once daily for 3 days
  • Concurrent intrapleural
    • tpa and DNase together with 2 hour clamping, followed by suction
    • BID for maximum 6 doses
  • Concurrent vs sequential
    • tpa/dnase together, clamp 1 hour, suction 1 hour vs tpa/dnase separate
    • BID for maximum 6 doses