coagulation DIC
- related: Hematology
- tags: #literature #hemeonc
ISTH score
- can sometimes be helpful
Treatment
- best treatment: is treating underlying disorder
Stages of DIC
- Stage 0: pre DIC
- not clinically evident
- coagulation cascade revved up
- fibinogen increase as result of acute phase reactant
- platelets increase
- antithrombin III sufficient
- similar to pre DM
- immunothrombosis
- pro inflammatory state
- Stage 1 DIC: thrombogenic state
- inflammatory cascade starting to cause problems that are visible
- overproduction of thrombin => clot formation
- antithrombin III
- activation of factor V and VIII
- activation of platelets