cocaine overdose leads to catecholamine excess


  • cocaine inhibits catecholamine uptake at synaptic cleft
  • symptoms are result of sympathetic stimulation: euphoria, mydriasis, tachycardia, hypertension, hallucination, anxiety, diaphoresis
  • result from cocaine overdose can affect multiple organs
    • neuro: lower seizure threshold, stroke
    • cardiac toxicity, MI, cardiomyopathy
    • lung: pneumothorax, bronchospasm
    • msk: hyperthermia, rhabdo1

Footnotes

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