DAPT


History

90s:

  • CURE trial: DAPT in ACS
    • ASA vs ASA and Plavix
    • Improvement in 24 hours, 30 days, and 1 year mortality
    • 2% ARR in composite (MI, stroke, death) 2000s
  • Prasugrel vs Plavix: TIMI 38?
  • Ticag vs Plavix: PLATO trial: same reduction + mortality benefit over tigag 2016
  • Prasugrel vs tigag: prasugrel barely better and safer
  • Prasugrel: 1x/day, generic, no dyspnea