ITP

  • Patients with asymptomatic mild thrombocytopenia (platelets >30,000/µL without bleeding) can generally be observed without treatment.
  • Corticosteroids are a first-line treatment option for patients with symptoms and/or a platelet count of <30,000/µL; the majority of adults respond within 1-2 weeks.
  • Intravenous immunoglobulin can be considered in patients who have failed or have contraindications to steroid therapy or require a more rapid increase in platelet counts.
  • Anti-Rh(D) is an alternate treatment option in rhesus-positive non-splenectomized patients.
  • Rituximab can be considered for patients who have failed initial treatment. Splenectomy is generally reserved for refractory cases .