ITP
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- Patients with asymptomatic mild thrombocytopenia (platelets >30,000/µL without bleeding) can generally be observed without treatment.
- Corticosteroids are a first-line treatment option for patients with symptoms and/or a platelet count of <30,000/µL; the majority of adults respond within 1-2 weeks.
- Intravenous immunoglobulin can be considered in patients who have failed or have contraindications to steroid therapy or require a more rapid increase in platelet counts.
- Anti-Rh(D) is an alternate treatment option in rhesus-positive non-splenectomized patients.
- Rituximab can be considered for patients who have failed initial treatment. Splenectomy is generally reserved for refractory cases .
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