tpa contraindications in stroke

Contraindications to fibrinolysis with tPA include:

  • Presence of active internal bleeding
  • Bleeding diathesis (eg, platelets <100,000/µL)
  • Hypodensity in >33% of an arterial territory on CT scan
  • Presence of intracranial hemorrhage on CT scan
  • Intracranial surgery in the last 3 months
  • Blood pressure >185/110 mm Hg