use of brensocatib reduces exacerbation in bronchiectasis

• related: chronic bronchiectasis
• tags: #permanent #pulmonology

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• bronchiectasis have higher level of neutrophils with elevated IL-8
• WILLLOW trial showed reduced exacerbation in 24 week period, lower level of neutrophil inflammation and elastase¹
• ASPEN trial: use of rensocatib lowers annual exacerbation rate and decline of FEV1²

Links to this note

• chronic bronchiectasis

  • use of brensocatib reduces exacerbation in bronchiectasis

• pathogenesis of chronic bronchiectasis from infection

  • infection leads to neutrophil inflammation and elevated proteases (use of brensocatib reduces exacerbation in bronchiectasis)

Footnotes

1. Bronchiectasis Lecture by Jennifer Krall? ↩

2. Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis ↩