use of brensocatib reduces exacerbation in bronchiectasis

• related: chronic bronchiectasis
• tags: #permanent #pulmonology

• bronchiectasis have higher level of neutrophils with elevated IL-8
• WILLLOW trial showed reduced exacerbation in 24 week period, lower level of neutrophil inflammation and elastase ¹

Links to this note

• chronic bronchiectasis
  • use of brensocatib reduces exacerbation in bronchiectasis
• pathogenesis of chronic bronchiectasis from infection
  • infection leads to neutrophil inflammation and elevated proteases (use of brensocatib reduces exacerbation in bronchiectasis)