use prothrombin time to rule out dabigatran related bleeding


  • thrombin time has high sensitivity and low specificity for dabigatran
  • normal thrombin time is highly sensitive to rule out therapeutic dabigatran therapy
  • medications other than dabigatran can cause high thrombin time1

Footnotes

  1. Pollack CV Jr, Reilly PA, van Ryn J, et al. Idarucizumab for dabigatran reversal - full cohort analysis. N Engl J Med. 2017;377(5):431-441. Save