clevidipine can cause hypoxemia via pulmonary shunting


Normal physiology: hypoxic pulmonary vasoconstriciton

Cleviprex dilates pulmonary vessels and leads to decreased V/Q ratio (pulmonary shunting)

vasopressor may be better because it does not act on pulmonary vasculatures.1 In contrast, inhaled pulmonary vasodilators such as epoprostenol does not cause hypoxic pulmonary vasoconstriction.

Footnotes

  1. https://europepmc.org/article/med/31770132