Fundamentals of High Resolution Lung CT


Hypersensitivity pneumonitis

  • HP hypersensitivity pneumonitis
  • p186
    • HP is result of immune reaction to organic inhalants
    • acute HP is rare: moldy hay in farmer's lung is an example
    • subacute HP most common in weeks to months
      • histologically represented by inflammation
    • chronic HP causes fibrosis
    • bronchiolocentric and poorly formed granulomas a compared to well formed in sarcoidosis
  • p187
    • subacute HP image finding includes GGO, centrilobular nodules, mosaicism, headcheese sign (combination of GO and mosaicism), mid lower lung distribution, spares costophrenic angles
    • centrilobular nodule reflects peribronchovascular inflammation, poorly marginated granuloma, cellular infiltration
  • p188
    • centrilobular nodules usually associated with low attenuation areas of mosaic perfusion (headcheese sign)
  • p189
    • distribution usually in mid lung and more central as compared to peripheral and lower lung in other interstitial pneumonias