HLH associated with malignancy
- related: Oncology, HLH hemaphagocytic lymphohistiocytosis HLH
- tags: #literature #hemeonc
- similar to CRS
- malignancy, infection in malignancy, treatment can all cause HLH
- in cancer patients with active therapy
- HLH in autoimmune flavor (scleroderma) => call it macrophage activation syndrome
- very high ferritin (>15,000)
- elevated IL2 receptor with positive CD25 subunit
- low fibrinogen
- important to exclude active infection (2ndary HLH) prior targeted therapy (very high risk)
- etoposide +/- steroids, IL6, complement suppression etc.1