lupus pernio is sarcoid skin problem and not related to lupus


Lupus pernio is sarcoidosis of the nose and central face, manifesting as violaceous subcutaneous plaques or nodules, often with some overlying scaling. Lupus pernio is more common in skin of color and is associated with an increased risk for extracutaneous disease, particularly intrathoracic sarcoidosis. Sarcoid lesions may also preferentially develop in sites of trauma, and these lesions are also associated with an increased risk of pulmonary disease. Other more common cutaneous manifestations of sarcoidosis include violaceous papules on the nose, periorbitally and around the oropharynx, and nasal openings.

The term “lupus pernio” is a source of potential confusion. “Lupus” generally refers to systemic lupus erythematosus; “pernio” generally refers to a condition of purple papules on the distal digits exacerbated by cold and moisture; and lupus vulgaris is a form of tuberculosis of the skin. Lupus pernio has little to do with these, however.1

2

Footnotes

  1. Cutaneous Manifestations of Internal Disease 2

  2. OPPM sarcoidosis