steven johnson syndrome causes include seizure medications

• related: steven johnson syndrome
• tags: #literature #dermatology #icu

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Essentially all cases of TEN are temporally correlated with medications (Table 27), whereas about 25% of SJS cases are caused by infection or vaccination.

HIV infection, kidney disease, uncontrolled autoimmune disease, and human leukocyte antigen type (HLA-B_1502 and HLA-B_5801) also contribute to increased risk.

Patients of Asian and South Asian ancestry who are positive for HLA-B_1502 have up to a 10% risk for SJS/TEN when exposed to aromatic anticonvulsants (carbamazepine, phenytoin, and phenobarbital).

HLA-B_5801 positivity predicts risk of SJS/TEN upon exposure to allopurinol. The role of genetic screening to prevent these reactions is unsettled.¹

• phenobarbital use have increased risk for steven johnson syndrome
• very similar to DRESS syndrome medications
  • DRESS syndrome causes

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• steven johnson syndrome

  • steven johnson syndrome causes include seizure medications

• DRESS syndrome causes

  • very similar to SJS causes (steven johnson syndrome causes include seizure medications)

• differentiate between SJS and DRESS syndrome

  • steven johnson syndrome causes include seizure medications

Footnotes

1. MKSAP ↩