eosinophilic granulomatosis with polyangitis aka churg strauss

Demographics

  • young adult

Pathogenesis

  • small to medium vessel vasculitis

Symptoms

  • adult onset asthma with palpable purpura refractory to medical treatment
  • atopy history, sinusitis
  • less renal involvement
  • eosinophilia
  • p-ANCA positive
  • Atopy and vasculitis
  • asthma
  • Asymmetric multifocal neuropathy (mononeuritis multiplex) is particularly common due to the vasculitis affecting the epineural vessels (eg, wrist drop due to radial nerve involvement).
  • Other common manifestations include skin nodules, migratory/transient pulmonary infiltrates, and paranasal sinus abnormalities. In addition to peripheral eosinophilia, a frequent laboratory finding is antibodies against neutrophil myeloperoxidase, which most commonly have a pattern of perinuclear staining (p-ANCA).1

Footnotes

  1. Uworld Questionnaires ↩ ↩2