eosinophilia and lung disorders
- related: Pulmonology
- tags: #permanent #pulmonology
The most common eosinophilic lung disorders are asthma and COPD with eosinophilia. These patients usually have normal chest xray and no fever.
If a patient has asthma like symptoms with skin or eye involvement (mononeuritis multiplex), one should consider EGPA (eosinophilic granulomatosis with polyangitis aka churg strauss).
If a patient has recurrent hospitalizations for pneumonia, differential should include eosinophilic pneumonia (acute and chronic eosinophilic pneumonia AEP and CEP). Fever, cough, and abnormal chest xray are first clues. diagnostic algorithm for eosinophilic pneumonia.
Patients with CF, asthma, and severe COPD should be considered for APBA (Allergic bronchopulmonary aspergillosis ABPA), especially if they have characteristic chest imaging (ABPA image findings include central, asymmetric bronchiectasis, bronchial wall thickening, and mucoid impaction.
A rare condition called hypereosinophilic obliterative bronchiolitis should be considered if there's characteristic signs of bronchiolitis on HRCT.
Infections as result of Loffler's syndrome should be considered.
Lastly, drugs and toxins can cause high eosinophils. These include NSAIDS, antibiotics (e.g. nitrofurantoin, minocycline, daptomycine)1
Links to this note
- Pulmonology
- Allergic bronchopulmonary aspergillosis ABPA
- peripheral eosinophilia (eosinophilia and lung disorders)