propofol infusion syndrome is associated with high dose continuous infusion

• related: ICU sedation
• tags: #permanent

• PRIS is propofol related infusion syndrome
• Associated with continuous infusion > 48 hours at high doses (> 70 mcg/kg/min)
• symptoms include bradycardia, metabolic acidosis with lactic acidosis (propofol infusion syndrome can lead to elevated lactic acidosis), rhabdo, AKI, cardiogenic shock
• checking triglyceride levels can help avoid infusion syndrome (stop propofol when triglycerides are over 500?)
• treatment includes stopping propofol ¹

Links to this note

• anion gap metabolic acidosis
  • Paracetamol/acetaminophen, paraldehyde, pyroglutamic acidosis, polyethylene glycol (miralax, metabolizes to lactic acid; versed, in the preparation, in neuro icu), propofol infusion syndrome can lead to elevated lactic acidosis, propofol infusion syndrome is associated with high dose continuous infusion: Brugada syndrome
• ICU sedation
  • propofol infusion syndrome is associated with high dose continuous infusion
• use propofol and precedex combination to minimize agitation and delirium
  • propofol alone can cause propofol infusion syndrome, metabolic acidosis. propofol infusion syndrome is associated with high dose continuous infusion