lactic acidosis types
- related: anion gap metabolic acidosis, ICU intensive care unit
- tags: #literature
Type A
- metformin associated lactic acidosis MALA
- polyethylene glycol (miralax, metabolizes to lactic acid; versed, in the preparation, in neuro icu)
- propofol infusion syndrome can lead to elevated lactic acidosis
- cyanide toxicity leads to elevated lactate
Type B
- not associated with tissue hypoxia
- beta agonist usage can lead to lactic acidosis in asthma
- propofol infusion syndrome can lead to elevated lactic acidosis
- metformin associated lactic acidosis MALA
- short bowel syndrome can cause D lactic acidosis
- decreased clearance: malignancy, liver dysfunction, drugs (linezolid, HAART, maybe metformin)
Links to this note
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- L: lactate lactic acidosis types
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propofol infusion syndrome can lead to elevated lactic acidosis
- related: lactic acidosis types
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beta agonist usage can lead to lactic acidosis in asthma
- related: lactic acidosis types
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metformin associated lactic acidosis MALA
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related: anion gap metabolic acidosis, lactic acidosis types
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MALA is an uncommon but potentially life-threatening complication of both chronic metformin use and acute overdose. The associated mortality is 30% to 50%. MALA is a form of type B lactic acidosis, not associated with tissue hypoxia (lactic acidosis types). The mechanism of lactic acidosis appears to be via its interaction with cytochrome complexes I and IV, resulting in impaired oxidative phosphorylation. Metformin toxicity tends to result in very high serum lactate levels, in comparison with type A lactic acidoses; one study demonstrated median lactate levels of 53.15 mg/dL (5.9 mmol/L) in septic shock, compared with median levels of 132.43 mg/dL (14.7 mmol/L) in MALA.
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short bowel syndrome can cause D lactic acidosis
- related: lactic acidosis types
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use pyruvate ratio to determine types of lactic acidosis
- related: lactic acidosis types