Biostats and Study Design

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• related: Step 3, Medicine

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MISC

• power and confidence level of research
• type 1 and 2 errors

Study Designs

• study designs
• explanatory vs pragmatic trials
• cross over study allows subjects to act as own control
• noninferiority trials
• validation methods in big data analysis
• clinical equipoise is uncertainty that one treatment is better than the other

Statistic Calculations

• high sensitivity rules out, high specificity rules in
• positive predictive value
• sensitivity, specificity, PPV, NPV, true positive, false positive, true negative, false negative
• PPV has positive relationship with prevalence
• mean, median, mode
• sensitivity analysis
• comparison tests in statistics
• per year rates
• relative risk vs odds ratio
• hazard ratio vs relative risk
• coefficient of determination
• attributable risk
• likelihood ratios
• relative risk reduction
• multiplicity phenomenon
• number needed to screen and prevalence
• calculating efficacy
• calculating survival probability
• person time rate
• NNT numbers needed to treat limitations

Avoiding Bias

• bias
• intention to treat preserves randomization and prevents selection bias
• competing risk of death
  • Competing Risk of Death - An Important Consideration in Studies of Older Adults
• using prespecified subgroups is stronger study design than post-hoc subgroup
• internal vs external validity

Analysis Methods

• Kaplan Meier survival curve and Cox proportional hazards model
• funnel plot
• linear regression
• time to event analysis
• propensity matching
• receiver operating characteristics curve
• means end analysis

Links to this note

• Medicine

  • Biostats and Study Design

• Competing Risk of Death - An Important Consideration in Studies of Older Adults

  • related: Biostats and Study Design, competing risk of death

• competing risk of death

  • related: Biostats and Study Design, Competing Risk of Death - An Important Consideration in Studies of Older Adults

• high sensitivity rules out, high specificity rules in

  • related: Biostats and Study Design

• cross over study allows subjects to act as own control

  • related: Biostats and Study Design

• explanatory vs pragmatic trials

  • related: Biostats and Study Design

• attributable risk

  • related: Biostats and Study Design

• bias

  • related: Biostats and Study Design

• calculating efficacy

  • related: Biostats and Study Design

• calculating survival probability

  • related: Biostats and Study Design

• clinical equipoise is uncertainty that one treatment is better than the other

  • related: Biostats and Study Design

• coefficient of determination

  • related: Biostats and Study Design

• comparison tests in statistics

  • related: Biostats and Study Design

• funnel plot

  • related: Biostats and Study Design

• hazard ratio vs relative risk

  • related: Biostats and Study Design

• intention to treat preserves randomization and prevents selection bias

  • related: Biostats and Study Design

• internal vs external validity

  • related: Biostats and Study Design

• likelihood ratios

  • related: Biostats and Study Design

• linear regression

  • related: Biostats and Study Design

• means end analysis

  • related: Biostats and Study Design

• multiplicity phenomenon

  • related: Biostats and Study Design

• NNT numbers needed to treat limitations

  • related: Biostats and Study Design

• noninferiority trials

  • related: Biostats and Study Design

• number needed to screen and prevalence

  • related: Biostats and Study Design

• person time rate

  • related: Biostats and Study Design

• per year rates

  • related: Biostats and Study Design

• positive predictive value

  • related: Biostats and Study Design

• power and confidence level of research

  • related: Biostats and Study Design

• PPV has positive relationship with prevalence

  • related: Biostats and Study Design

• propensity matching

  • related: Biostats and Study Design

• receiver operating characteristics curve

  • related: Biostats and Study Design

• relative risk reduction

  • related: Biostats and Study Design

• relative risk vs odds ratio

  • related: Biostats and Study Design

• sensitivity, specificity, PPV, NPV, true positive, false positive, true negative, false negative

  • related: Biostats and Study Design

• sensitivity analysis

  • related: Biostats and Study Design

• study designs

  • related: Biostats and Study Design

• time to event analysis

  • related: Biostats and Study Design

• type 1 and 2 errors

  • related: Biostats and Study Design

• validation methods in big data analysis

  • related: Biostats and Study Design